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So far most of the trials in this area have been small and led by academic investigators

15 As such, GIP, secreted by enteroendocrine K-cells, and GLP-1, released from corresponding intestinal L-cells, collectively referred to as the incretin hormones, are well-studied for their roles in glucose homeostasis and energy balance

S., Rayner, C

Marks points out that at that time the two hormones produced by pancreatic islet A and B cells were regarded as 'biological antagonists rather than subtle collaborators in blood glucose control' (Marks 2018)